Rap guanine nucleotide exchange factor (GEF) 4 Adenovirus
Cat. No: 1392
Epac (exchange protein directly activated by cAMP; also designated cAMP-GEFI) and Epac2 (also designated cAMP-GEFII) compose a novel family of cyclic AMP activated guanine-nucleotide exchange factors (GEFs). Both Epac and Epac2 contain cAMP-binding motifs and a motif common to Ras superfamily GEFs. Epac and Epac2 both function to activate Rap1, a Ras-like GTPase that is known to suppress the oncogenic transformation of cells by Ras. Epac is ubiquitously expressed, whereas Epac2 is primarily expressed in the brain and adrenal glands.
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
- Gene Symbol
- Gene ID
- Gene Synonyms
This product is referenced in the following publications:
- Olof Idevall-Hagren, etc (2013). Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic ß Cells. Science Signal.
- Oleg G. Chepurny, etc (2013). Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Molecular Endocrinology.
- Kelly P, etc (2010). Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation. J Biol Chem.