Rap guanine nucleotide exchange factor (GEF) 4 Adenovirus
Epac (exchange protein directly activated by cAMP; also designated cAMP-GEFI) and Epac2 (also designated cAMP-GEFII) compose a novel family of cyclic AMP activated guanine-nucleotide exchange factors (GEFs). Both Epac and Epac2 contain cAMP-binding motifs and a motif common to Ras superfamily GEFs. Epac and Epac2 both function to activate Rap1, a Ras-like GTPase that is known to suppress the oncogenic transformation of cells by Ras. Epac is ubiquitously expressed, whereas Epac2 is primarily expressed in the brain and adrenal glands.
1392
Ad-EPAC2
Ready-to-use Rap guanine nucleotide exchange factor (GEF) 4 Adenovirus. Ad-RAPGEF4/EPAC2, Rap guanine nucleotide exchange factor (GEF) 4, CGEF2,EPAC2,RAPGEF4,CAMP-GEFII adenovirus 1392
Gene Reference Data
Alternate Names
CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496
Gene ID
11069
Gene Name (Vector)
Rap guanine nucleotide exchange factor 4
Gene Symbol
RAPGEF4
HGNC ID
HGNC:16626
ORF Size (aa)
3036
ORF Size (bp)
3036 bp
RefSeq ID
NM_007023
RefSeq Synonyms
NM_007023, NM_001282901, NM_001282900, NM_001282899, NM_001100397, BC040183, BC024004,
Species
human
UniGene ID
Hs.470646
Related Citations
- Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic ß Cells. Olof Idevall-Hagren, etc, (2013), Science Signal
- Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Oleg G. Chepurny, etc, (2013), Molecular Endocrinology
- Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation. Kelly P, etc, (2010), J Biol Chem
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.