Rap guanine nucleotide exchange factor (GEF) 3 Adenovirus
Epac (exchange protein directly activated by cAMP; also designated cAMP-GEFI) and Epac2 (also designated cAMP-GEFII) compose a novel family of cyclic AMP activated guanine-nucleotide exchange factors (GEFs). Both Epac and Epac2 contain cAMP-binding motifs and a motif common to Ras superfamily GEFs. Epac and Epac2 both function to activate Rap1, a Ras-like GTPase that is known to suppress the oncogenic transformation of cells by Ras. Epac is ubiquitously expressed, whereas Epac2 is primarily expressed in the brain and adrenal glands.
1387
Ad-EPAC1
Ready-to-use Rap guanine nucleotide exchange factor (GEF) 3 Adenovirus. Ad-EPAC1, Rap guanine nucleotide exchange factor (GEF) 3, EPAC,EPAC1,BCM910,RAPGEF3,MGC21410,CAMP-GEFI adenovirus 1387
Gene Reference Data
Alternate Names
bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Gene ID
10411
Gene Name (Vector)
Rap guanine nucleotide exchange factor 3
Gene Symbol
RAPGEF3
HGNC ID
HGNC:16629
ORF Size (aa)
2772
ORF Size (bp)
2772 bp
RefSeq ID
NM_006105
RefSeq Synonyms
NM_006105, NM_001098532, NM_001098531, BC092404, BC017728,
Species
human
UniGene ID
Hs.8578
Related Citations
- Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: A role for EPAC in Lesch-Nyhan Syndrome. Ghiabe-Henri Guibinga, ect, (2013), Human Molecular Genetics
- Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation. Kelly P, etc, (2010), J Biol Chem
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.