Rap guanine nucleotide exchange factor (GEF) 3 Adenovirus
Cat. No: 1387
Epac (exchange protein directly activated by cAMP; also designated cAMP-GEFI) and Epac2 (also designated cAMP-GEFII) compose a novel family of cyclic AMP activated guanine-nucleotide exchange factors (GEFs). Both Epac and Epac2 contain cAMP-binding motifs and a motif common to Ras superfamily GEFs. Epac and Epac2 both function to activate Rap1, a Ras-like GTPase that is known to suppress the oncogenic transformation of cells by Ras. Epac is ubiquitously expressed, whereas Epac2 is primarily expressed in the brain and adrenal glands.
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
- Gene Symbol
- Gene ID
- Gene Synonyms
This product is referenced in the following publications:
- Ghiabe-Henri Guibinga, ect (2013). Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: A role for EPAC in Lesch-Nyhan Syndrome. Human Molecular Genetics.
- Kelly P, etc (2010). Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation. J Biol Chem.