SMAD, mothers against DPP homolog 2 Adenovirus
Mammalian homologs of the Drosophila Mad gene include Smad1 (also designated Madr1 or JV4-1), Smad2 (also designated Madr2 or JV18-1), Smad3, Smad4 (also designated DPC4), Smad5, Smad6, Smad7 and Smad8 (also designated Smad9). Smad1 and Smad5 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGFb and activin-mediated growth modulation. Smad4 is required for all of the above activities and necessitates FAST-1 for DNA binding. Smad6 and Smad7 regulate the response to activin/ TGF-beta signaling by interfering with TGF-beta-mediated phosphorylation of other Smad family members.
1386
Ad-SMAD2
Ready-to-use SMAD, mothers against DPP homolog 2 Adenovirus. Ad-SMAD2, “SMAD, mothers against DPP homolog 2”, JV18,MADH2,MADR2,SMAD2,HMAD-2,HSMAD2,JV18-1,MGC22139,MGC34440 adenovirus 1386
Gene Reference Data
Alternate Names
hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; MADH2; MADR2; Mad-related protein 2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Smad2
Description (eCommerce)
SMAD2 belongs to the SMAD family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. [taken from NCBI Entrez Gene (Gene ID: 4087)].
Description (Vector)
SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
4087
Gene Name (eCommerce)
SMAD family member 2
Gene Name (Vector)
SMAD family member 2
Gene Symbol
SMAD2
HGNC ID
HGNC:6768
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
Protein Name (eCommerce)
Mothers against decapentaplegic homolog 2
RefSeq ID
NM_005901
RefSeq Synonyms
NM_005901, NM_001135937, NM_001003652, BC025699, BC014840,
Research Areas
Breast Cancer,Cancer,Cardiac Development,Cardiovascular,Cell Cycle,Colorectal Cancer,EGFR Signaling,Gene Expression,Hippo Signaling,Host-Virus Interactions,Immunology,Prostate Cancer,RNA Processing,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,cardiovascular,cell_biology,cell_cycle,signal_transduction,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,genetics,transcription_translation,signal_transduction,immunology,genetics,transcription_translation,developmental_biology
Species
human
Target Sentence
SMAD2 belongs to the SMAD family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD2 mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. [taken from NCBI Entrez Gene (Gene ID: 4087)].
UniGene ID
Hs.705764
UniProt ID (eCommerce)
Q15796
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.