Endothelin 1 Adenovirus
Category: Adenovirus > Over-Expression
Cat. No: 1373
The endothelins are family of cysteine-rich peptides consisting of 21-amino acid and containing two intramolecular disulfide bridges that exert their vasoactive and mitogenic actions through G protein-coupled receptors. At the present, the existence of three active isoforms of ET (-1, -2, and -3), and two distinct receptors, ETA and ETB, is well documented (17). The active form of ET-1 arises from biologically inactive big-ET-1 through the action of a specific protease that removes 18 amino acids from its carboxyl terminal. This membrane-bound metallopeptidase, characterized by its sensitivity to phosphoramidon, is known as endothelin-converting enzyme-1 (ECE-1) . A growing body of evidence indicate that ET-1 is a major player in numerous disease states including congestive heart failure, pulmonary fibrosis, obesity and diabetes, as well as a key mediator of tissue repair and normal wound healing.
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
- Gene Symbol
- Gene ID
- Gene Synonyms
This product is referenced in the following publications:
- Lagares D, etc (2012). Adenoviral Gene Transfer of Endothelin-1 in the Lung Induces Pulmonary Fibrosis through the Activation of Focal Adhesion Kinase. Am J Respir Cell Mol Biology.
- J Zhang, etc (2019). PKC-Mediated Endothelin-1 Expression in Endothelial Cell Promotes Macrophage Activation in Atherogenesis. American Journal of Hypertension.
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