Endothelin 1 Adenovirus

Name 
Ad-ET-1
Cat No 
1373
Availability
Immediate

The endothelins are family of cysteine-rich peptides consisting of 21-amino acid and containing two intramolecular disulfide bridges that exert their vasoactive and mitogenic actions through G protein-coupled receptors. At the present, the existence of three active isoforms of ET (-1, -2, and -3), and two distinct receptors, ETA and ETB, is well documented (17). The active form of ET-1 arises from biologically inactive big-ET-1 through the action of a specific protease that removes 18 amino acids from its carboxyl terminal. This membrane-bound metallopeptidase, characterized by its sensitivity to phosphoramidon, is known as endothelin-converting enzyme-1 (ECE-1) . A growing body of evidence indicate that ET-1 is a major player in numerous disease states including congestive heart failure, pulmonary fibrosis, obesity and diabetes, as well as a key mediator of tissue repair and normal wound healing.

1373
Ad-ET-1

Ready-to-use Endothelin 1 Adenovirus. Ad-ET-1, Endothelin 1, ET1,EDN1 adenovirus 1373

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ARCND3; ET1; HDLCQ7; PPET1; QME
Description (Vector)
EDN1 is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1906
Gene Name (Vector)
endothelin 1
Gene Symbol
EDN1
HGNC ID
HGNC:3176
ORF Size (aa)
639
ORF Size (bp)
639 bp
RefSeq ID
NM_001955
RefSeq Synonyms
NM_001955, NM_001168319, BC009720,
Species
human
UniGene ID
Hs.713645

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.