Endothelin 1 Adenovirus
The endothelins are family of cysteine-rich peptides consisting of 21-amino acid and containing two intramolecular disulfide bridges that exert their vasoactive and mitogenic actions through G protein-coupled receptors. At the present, the existence of three active isoforms of ET (-1, -2, and -3), and two distinct receptors, ETA and ETB, is well documented (17). The active form of ET-1 arises from biologically inactive big-ET-1 through the action of a specific protease that removes 18 amino acids from its carboxyl terminal. This membrane-bound metallopeptidase, characterized by its sensitivity to phosphoramidon, is known as endothelin-converting enzyme-1 (ECE-1) . A growing body of evidence indicate that ET-1 is a major player in numerous disease states including congestive heart failure, pulmonary fibrosis, obesity and diabetes, as well as a key mediator of tissue repair and normal wound healing.
Ready-to-use Endothelin 1 Adenovirus. Ad-ET-1, Endothelin 1, ET1,EDN1 adenovirus 1373
Gene Reference Data
Related Citations
- PKC-Mediated Endothelin-1 Expression in Endothelial Cell Promotes Macrophage Activation in Atherogenesis. J Zhang, etc, (2019), American Journal of Hypertension
- Adenoviral Gene Transfer of Endothelin-1 in the Lung Induces Pulmonary Fibrosis through the Activation of Focal Adhesion Kinase. Lagares D, etc, (2012), Am J Respir Cell Mol Biology