MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) Adenovirus

Name 
Ad-MEF2A
Cat No 
1369
Availability
Immediate
Categories
Adenovirus, Over-Expression

Differentiation of myogenic cells is regulated by multiple positive and negative regulators. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5, Myf-6 (also designated MRF-4 or herculin) and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, ITF2 and HEB. The E2A gene encodes at lest two different proteins, E12 and E47, as a result of alternative splicing. The myocyte enhancing factor-2 (MEF-2) family of transcription factors includes four splice variants A, B, C and D which encode muscle-specific DNA binding proteins that recognize an A/T rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes.

1369
Ad-MEF2A

Ready-to-use MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) Adenovirus. Ad-MEF2A, “MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)”, MEF2A,ADCAD1,RSRFC4,RSRFC9 adenovirus 1369

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
ADCAD1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); mef2; myocyte-specific enhancer factor 2A; RSRFC4; RSRFC9; serum response factor-like protein 1
Description (eCommerce)
Myocyte enhancer factor 2A (MEF2A) is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [taken from NCBI Entrez Gene (Gene ID: 4205)].
Description (Vector)
MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
4205
Gene Name (eCommerce)
myocyte enhancer factor 2A
Gene Name (Vector)
myocyte enhancer factor 2A
Gene Symbol
MEF2A
HGNC ID
HGNC:6993
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
Protein Name (eCommerce)
Myocyte-specific enhancer factor 2A
RefSeq ID
NM_005587
RefSeq Synonyms
NM_005587, NM_001319206, NM_001171894, NM_001130928, NM_001130927, NM_001130926, BC053871, BC013437,
Research Areas
Apoptosis,BDNF Signaling,Cardiac Development,Cardiology,Cardiovascular,Immunology,Innate Immunity,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,RNA Binding,Signal Transduction,Toll-like Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Myocyte enhancer factor 2A (MEF2A) is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [taken from NCBI Entrez Gene (Gene ID: 4205)].
UniGene ID
Hs.268675
UniProt ID (eCommerce)
Q02078

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.