cAMP responsive element binding protein 1 Adenovirus

Name 
Ad-CREB1
Cat No 
1363
Availability
Immediate
Categories
Adenovirus, Over-Expression

The ATF/CREB family consists of a series of transcription factors that function by binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, LZIP (also designated CREB3 and Luman), CREM-2, ATF-1, ATF-2, ATF-3, ATF-4, ATF-6 and ATF-7. These transcription factors share terminal leucine zipper dimerization and basic DNA binding domains and are highly variable in their N-termini. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, they can also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. Protein kinase A-mediated CREB phosphorylation induces association with a 265 kDa nuclear protein designated CBP (CREB-binding protein), which may represent a CREB coactivator.

1363
Ad-CREB1

Ready-to-use cAMP responsive element binding protein 1 Adenovirus. Ad-CREB1, cAMP responsive element binding protein 1, CREB adenovirus 1363

$475.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; transactivator protein
Description (eCommerce)
CREB (cyclic AMP response element-binding protein) is a ubiquitously expressed transcription factor that binds cAMP response elements to regulate gene transcription for various cellular responses such as glucose homeostasis, growth-factor dependent survival, and proliferation. CREB is also implicated to play a role in memory and mood.
Description (Vector)
CREB1 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
1385
Gene Name (eCommerce)
cAMP responsive element binding protein 1
Gene Name (Vector)
cAMP responsive element binding protein 1
Gene Symbol
CREB1
HGNC ID
HGNC:2345
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
984
ORF Size (bp)
984 bp
Protein Name (eCommerce)
Cyclic AMP-responsive element-binding protein 1
RefSeq ID
NM_004379
RefSeq Synonyms
NM_134442, NM_004379, NM_001320793, BC095407, BC010636,
Research Areas
Alzheimer's Disease,Antigen Processing and Presentation,Apoptosis,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,Host-Virus Interactions,Huntington's Disease,Hypoxia,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,Leptin Signaling,LKB1 Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,NGF Signaling,Notch Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TSH Signaling,VEGF Signaling,Viral Carcinogenesis,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
CREB (cyclic AMP response element-binding protein) is a ubiquitously expressed transcription factor that binds cAMP response elements to regulate gene transcription for various cellular responses such as glucose homeostasis, growth-factor dependent survival, and proliferation. CREB is also implicated to play a role in memory and mood.
UniGene ID
Hs.516646
UniProt ID (eCommerce)
P16220

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.