Peroxisome proliferative activated receptor, gamma Adenovirus
The protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
1354
Ad-PPAR(gamma)
Ready-to-use Peroxisome proliferative activated receptor, gamma Adenovirus. Ad-PPAR(gamma), “Peroxisome proliferative activated receptor, gamma “, NR1C3,PPARG,PPARG1,PPARG2,HUMPPARG adenovirus 1354
Gene Reference Data
Alternate Names
CIMT1; GLM1; NR1C3; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; PPARG1; PPARG2; PPARgamma; PPAR-gamma
Description (eCommerce)
PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPAR-gamma is a key regulator of adipocyte differentiation and glucose homeostasis and acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37231].
Description (Vector)
PPARG encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Gene ID
5468
Gene Name (eCommerce)
peroxisome proliferator activated receptor gamma
Gene Name (Vector)
peroxisome proliferator activated receptor gamma
Gene Symbol
PPARG
HGNC ID
HGNC:9236
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1434
ORF Size (bp)
1434 bp
Protein Name (eCommerce)
Peroxisome proliferator-activated receptor gamma
RefSeq ID
NM_138712
RefSeq Synonyms
NM_138712, NM_138711, NM_015869, NM_005037, NM_001330615, BC006811,
Research Areas
Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Estrogen Signaling,Gene Expression,Huntington's Disease,IFN Signaling,Immunology,Innate Immunity,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPAR-gamma is a key regulator of adipocyte differentiation and glucose homeostasis and acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37231].
UniGene ID
Hs.162646
UniProt ID (eCommerce)
P37231
Related Citations
- Dual PPARa/¿ activation inhibits SIRT1-PGC1a axis and causes cardiac dysfunction. C Kalliora, etc, (2019), JCI Insight.
- Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis. N Magee, etc, (2019), JBC
- Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPa-dependent manner. Hansson B, etc, (2017), PLoS ONE
- Enhanced Clearance of Pseudomonas aeruginosa by PPAR¿. B Bedi, etc, (2016), Infection and Immunity
- PPAR¿ depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation. Kaiser M. Bijli, etc, (2014), Free Radical Biology and Medicine
- Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity. Bosma M, etc, (2014), Biochim Biophys Acta
- Transforming growth factor-ß inhibits myocardial PPAR¿ expression in pressure overload-induced cardiac fibrosis and remodeling in mice. Gong, Kaizhenga, etc, (2011), Journal of Hypertension
- Mitochondrial Complex III ROS Regulate Adipocyte Differentiation. Tormos. K, etc, (2011), Cell Metabolism
- Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation. Hwang J. etc, (2011), PNAS
- The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/ß-Catenin Signaling Pathways. Guo W, etc, (2008), J Biol Chem
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.