This adenovirus expresses the human BRCA1 transcript variant 5 (NM_007299). This variant differs in the 5' UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. So this variant is shorter and has a distinct C-terminus, compared to BRCA1 isoform 1.
Please contact us if you need adenoviruses expressing other isoforms of human BRCA1.
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
- Gene Symbol
- Gene ID
- Gene Synonyms
This product is referenced in the following publications:
- H Teoh, etc (2012). BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis. Gene Therapy.
- Dimitrov SD, etc (2013). Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes & Development.