c-Myc (delta Myc) Adenovirus

Name 
Ad-deltaMyc
Cat No 
1286
Availability
Immediate
Categories
Adenovirus, Over-Expression

c-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. It is a mammalian transcription factor belonging to the bHLH (basic Helix Loop Helix)-Leucine Zipper family. The Myc family of cellular oncogenes, which includes c-Myc, N-Myc, L-Myc, S-Myc and B-Myc, represents nuclear transcription factors that play a significant role in cellular proliferation, differentiation, apoptosis and transformation. Members of this gene family are activated upon various mitogenic signals such as Wnt, Shh and EGF. They form heteromeric complexes with other interacting partners, such as members of the Max and Mad families, to activate transcription. Alternatively, c-Myc can also inhibit the DNA binding protein Miz-1 to repress a second set of target genes. Mnt and Mlx regulate Myc activity by forming heterodimers with Max or Mad, respectively, to suppress Myc-induced transcriptional activation.

This adenovirus contain a truncated c-Myc.

Reference: Hermeking H., et al., Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2229-34.

1286
Ad-deltaMyc

Ready-to-use c-Myc (delta Myc) Adenovirus. Truncated delta Myc δMyc 1286

$475.00
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Product Details

Reporter
eGFP
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.