TCF4 (dn) Adenovirus
T cell factor-4 (Tcf-4) plays an important role in development and carcinogenesis. It directly binds to cytosolic β-catenin and facilitate its translocation to the nucleus. In the nucleus, these complexes induce expression various target genes.
The adenovirus expresses a dominant negative TCF4.
Reference: He TC., et al., Science. 1998 Sep 4;281(5382):1509-12.
1281
Ad-TCF4 (dn)
Ready-to-use TCF4 (dn) Adenovirus. dominant negative TCF4 1281
Related Citations
- Hedgehog inhibits ß-catenin activity in synovial joint development and osteoarthritis. JS Rockel, etc, (2016), JCI
- Canonical Wnt signals combined with suppressed TGFß/BMP pathways promote renewal of the native human colonic epithelium. Amy Reynolds, etc, (2013), GUT
- Phosphorylation Of Beta-Catenin By PKA Promotes ATP-Induced Proliferation Of Vascular Smooth Muscle Cells. Taurin S, etc, (2008), Am J Physiol Cell Physiol
- The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/ß-Catenin Signaling Pathways. Guo W, etc, (2008), J Biol Chem
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.