human HSP70 Adenovirus
Heat shock protein Hsp70
1047
Ad-CMV-HSP70
Ready-to-use human HSP70 Adenovirus. HSP70 Heat shock protein adenovirus 1047
Gene Reference Data
Alternate Names
HSP70-1B; HSP70-2; HSP70.2
Description (Vector)
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Gene ID
3304
Gene Name (Vector)
heat shock protein family A (Hsp70) member 1B
Gene Symbol
HSPA1B
HGNC ID
HGNC:5233
ORF Size (aa)
1926
ORF Size (bp)
1926 bp
RefSeq ID
NM_005346
RefSeq Synonyms
NM_005346, BC063507, BC057397,
Species
human
UniGene ID
Hs.
Related Citations
- HSP70 alleviates PC-12 cell oxidative damage caused by ROS through activation of Wnt/beta-catenin signaling pathway in spinal cord injury. Shi K, etc, (2016), Int J Clin Exp Patho
- A Protective Hsp70¿TLR4 Pathway in Lethal Oxidant Lung Injury. Yi Zhang, etc, (2013), The Journal of Immunology
- Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Yacoub, A. etc, (2008), Molecular Cancer Therapeutics
- Osu-03012 Stimulates Pkr-Like Endoplasmic Reticulum-Dependent Increases In 70-Kda Heat Shock Protein Expression, Attenuating Its Lethal Actions In Transformed Cells. Park, M., etc., (2008), Mol Pharmacol
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.