Category: Adenovirus > Over-Expression
Cat. No: 1043
The retinoblastoma susceptibility protein Rb is a 110 kDa phosphorylated protein. Like p53, Rb p110 is an anti-oncogene that is subject to inactivation by either mutation or by binding to certain DNA tumor virus-encoded proteins. Rb binds to and regulates transcription factors involved in cell cycle regulation, including the E2F family. Two Rb related proteins, p107 and p130, also function to regulate specific members of the E2F transcription factor family. Binding and inactivation of E2F proteins by Rb is regulated by cyclin dependent kinase-mediated phosphorylation
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- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- CMV (ubiquitous)
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
- 1x10^10 PFU/ml
This product is referenced in the following publications:
- Arima, Y., etc. (2008). Rb Depletion Results In Deregulation Of E-Cadherin And Induction Of Cellular Phenotypic Changes That Are Characteristic Of The Epithelial-To-Mesenchymal Transition. Cancer Research.
- Erica P. Cai, etc (2014). Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action. Diabetologia.
- Jeon BN, etc (2008). Proto-Oncogene Fbi-1 (Pokemon/Zbtb7a) Represses Transcription Of The Tumor Suppressor Rb Gene Via Binding Competition With Sp1 And Recruitment Of Co-Repressors. J. Biol. Chem.
- X Zhao, etc (2018). Involvement of the STAT5-CyclinD/CDK4-pRb pathway in beta cell proliferation stimulated by prolactin during pregnancy. American Journal of Physiology-Endocrinology and Metabolism.
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