human ABCD4 shRNA silencing AAV

Name
AAV-h-ABCD4-shRNA

Cat No
shAAV-200089

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ABCD4.

shAAV-200089

AAV-h-ABCD4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABCD4 (ATP binding cassette subfamily D member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ABC41; EST352188; MAHCJ; P70R; P79R; PMP69; PXMP1L

Description (Vector)

ABCD4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding.

Gene ID

5826

Gene Name (Vector)

ATP binding cassette subfamily D member 4

Gene Symbol

ABCD4

HGNC ID

HGNC:68

ORF Size (aa)

1821

ORF Size (bp)

1821 bp

RefSeq ID

NM_005050

RefSeq Synonyms

NM_005050, BC012815,

Species

human

UniGene ID

Hs.94395

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.