human AANAT shRNA silencing AAV

Name
AAV-h-AANAT-shRNA

Cat No
shAAV-200024

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AANAT.

shAAV-200024

AAV-h-AANAT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AANAT (aralkylamine N-acetyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DSPS; SNAT

Description (Vector)

AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

Gene Name (Vector)

aralkylamine N-acetyltransferase

Gene Symbol

AANAT

HGNC ID

HGNC:19

ORF Size (aa)

624

ORF Size (bp)

624 bp

RefSeq ID

NM_001088

RefSeq Synonyms

NM_001166579, NM_001088, BC126334, BC126332, BC092430, BC069434,

Species

human

UniGene ID

Hs.431417

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.