human AADAT shRNA silencing AAV

Name
AAV-h-AADAT-shRNA

Cat No
shAAV-200019

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AADAT.

shAAV-200019

AAV-h-AADAT-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AADAT (aminoadipate aminotransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

KAT2; KATII; KYAT2

Description (Vector)

AADAT encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.

Gene ID

51166

Gene Name (Vector)

aminoadipate aminotransferase

Gene Symbol

AADAT

HGNC ID

HGNC:17929

ORF Size (aa)

1290

ORF Size (bp)

1290 bp

RefSeq ID

NM_016228

RefSeq Synonyms

NM_182662, NM_016228, NM_001286683, NM_001286682, BC031068,

Species

human

UniGene ID

Hs.529735

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.