human CIZ1 Over-expression AAV
This is an AAV expressing Human CIZ1.
AAV-205304
AAV-h-CIZ1
Ready-to-use AAV expressing Human CIZ1 (CDKN1A interacting zinc finger protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDKN1A-interacting zinc finger protein 1; cip1-interacting zinc finger protein; LSFR1; NP94; nuclear protein NP94; zinc finger protein 356; ZNF356
Description (eCommerce)
CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.
Description (Vector)
CIZ1 is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
25792
Gene Name (eCommerce)
CDKN1A interacting zinc finger protein 1
Gene Name (Vector)
CDKN1A interacting zinc finger protein 1
Gene Symbol
CIZ1
HGNC ID
HGNC:16744
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2514
ORF Size (bp)
2514 bp
Protein Name (eCommerce)
Cip1-interacting zinc finger protein
RefSeq ID
NM_012127
RefSeq Synonyms
NM_012127, NM_001257976, NM_001257975, NM_001131018, NM_001131017, NM_001131016, NM_001131015, BC021163, BC004119,
Research Areas
Cell Cycle,Nuclear Receptor Coactivators,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.
UniGene ID
Hs.212395
UniProt ID (eCommerce)
Q9ULV3
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.