human CHUK Over-expression AAV

Name
AAV-h-CHUK

Cat No
AAV-205262

Availability
4-5 weeks

This is an AAV expressing Human CHUK.

AAV-205262

AAV-h-CHUK

Ready-to-use AAV expressing Human CHUK (conserved helix-loop-helix ubiquitous kinase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Conserved helix-loop-helix ubiquitous kinase; IkappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkB kinase alpha subunit; IKBKA; IKK1; IKKA; IKK-A; IKK-a kinase; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha; TCF16; TCF-16; transcription factor 16

Description (eCommerce)

I kappa-B kinase-alpha (IKK-alpha) is part of the IKK complex composed of two regulatory subunits, IKK-alpha and IKK-beta, and a regulatory subunit, IKK-gamma/NEMO. The IKK complex functions to phosphorylate and inactivate I kappa B, an inhibitor of the NF-kappa B transcription factor.

Description (Vector)

CHUK encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Gene ID

1147

Gene Name (eCommerce)

conserved helix-loop-helix ubiquitous kinase

Gene Name (Vector)

conserved helix-loop-helix ubiquitous kinase

Gene Symbol

CHUK

HGNC ID

HGNC:1974

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2238

ORF Size (bp)

2238 bp

Protein Name (eCommerce)

Inhibitor of nuclear factor kappa-B kinase subunit alpha

RefSeq ID

NM_001278

RefSeq Synonyms

NM_001320928, NM_001278, BC092514,

Research Areas

Apoptosis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cell Cycle,Cytokine Signaling,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RANKL-RANK Signaling,Response to Virus,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,TWEAK Signaling,VEGF Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

Species

human

Target Sentence

UniGene ID

Hs.198998

UniProt ID (eCommerce)

O15111

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.