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human CD70 Over-expression AAV

Name 
AAV-h-CD70
Cat No 
AAV-204678
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CD70.

AAV-204678
AAV-h-CD70

Ready-to-use AAV expressing Human CD70 (CD70 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD70; CD27 ligand; CD27L; CD27-L; CD27LG; CD70 antigen; Ki-24 antigen; surface antigen CD70; TNFSF7; TNLG8A; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7
Description (eCommerce)
CD70, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family, is a ligand for TNFRSF27/CD27. CD70 is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. CD70 also plays a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. [taken from NCBI Entrez Gene (Gene ID: 970)].
Description (Vector)
CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Gene ID
970
Gene Name (eCommerce)
CD70 molecule
Gene Name (Vector)
CD70 molecule
Gene Symbol
CD70
HGNC ID
HGNC:11937
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
582
ORF Size (bp)
582 bp
Protein Name (eCommerce)
CD70 antigen
RefSeq ID
NM_001252
RefSeq Synonyms
NM_001330332, NM_001252, BC000725,
Research Areas
Apoptosis,Cancer,Immunology,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
CD70, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family, is a ligand for TNFRSF27/CD27. CD70 is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. CD70 also plays a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. [taken from NCBI Entrez Gene (Gene ID: 970)].
UniGene ID
Hs.715224
UniProt ID (eCommerce)
P32970

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.