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human CD3E Over-expression AAV

Name 
AAV-h-CD3E
Cat No 
AAV-204647
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CD3E.

AAV-204647
AAV-h-CD3E

Ready-to-use AAV expressing Human CD3E (CD3e molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE
Description (eCommerce)
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The epsilon polypeptide plays an essential role in T-cell development [taken from NCBI Entrez Gene (Gene ID: 916)].
Description (Vector)
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Gene ID
916
Gene Name (eCommerce)
CD3 epsilon subunit of T-cell receptor complex
Gene Name (Vector)
CD3e molecule
Gene Symbol
CD3E
HGNC ID
HGNC:1674
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
624
ORF Size (bp)
624 bp
Protein Name (eCommerce)
T-cell surface glycoprotein CD3 epsilon chain
RefSeq ID
NM_000733
RefSeq Synonyms
NM_000733, BC049847,
Research Areas
Apoptosis,Host-Virus Interactions,Immune Cells and Tumor Markers,Immunology,Immuno-Oncology,Interleukin Signaling,Neurobiology,NF-kB Signaling,Prolactin Signaling,Signal Transduction,immunology,cell_biology,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immuno_oncology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The epsilon polypeptide plays an essential role in T-cell development [taken from NCBI Entrez Gene (Gene ID: 916)].
UniGene ID
Hs.3003
UniProt ID (eCommerce)
P07766

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.