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human CD3D Over-expression AAV

Name 
AAV-h-CD3D
Cat No 
AAV-204645
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CD3D.

AAV-204645
AAV-h-CD3D

Ready-to-use AAV expressing Human CD3D (CD3d molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD3d; CD3 antigen, delta subunit; CD3 delta; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; IMD19; OKT3, delta chain; T3D; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain
Description (eCommerce)
The protein encoded for by CD3D, T-cell surface glycoprotein CD3 delta chain, is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. CD3 delta chain, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells [taken from NCBI Entrez Gene (Gene ID: 915)].
Description (Vector)
CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
Gene ID
915
Gene Name (eCommerce)
CD3d molecule
Gene Name (Vector)
CD3d molecule
Gene Symbol
CD3D
HGNC ID
HGNC:1673
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
516
ORF Size (bp)
516 bp
Protein Name (eCommerce)
T-cell surface glycoprotein CD3 delta chain
RefSeq ID
NM_000732
RefSeq Synonyms
NM_001040651, NM_000732, BC070321, BC039035,
Research Areas
Apoptosis,Host-Virus Interactions,Immunology,Interleukin Signaling,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,infectious_disease,immunology,signal_transduction
Species
human
Target Sentence
The protein encoded for by CD3D, T-cell surface glycoprotein CD3 delta chain, is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. CD3 delta chain, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells [taken from NCBI Entrez Gene (Gene ID: 915)].
UniGene ID
Hs.504048
UniProt ID (eCommerce)
P04234

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.