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human CCT4 Over-expression AAV

Name 
AAV-h-CCT4
Cat No 
AAV-204559
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CCT4.

AAV-204559
AAV-h-CCT4

Ready-to-use AAV expressing Human CCT4 (chaperonin containing TCP1 subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Cctd; CCT-DELTA; chaperonin containing t-complex polypeptide 1, delta subunit; chaperonin containing TCP1, subunit 4 (delta); SRB; stimulator of TAR RNA-binding; T-complex protein 1 subunit delta; TCP-1-delta
Description (eCommerce)
Chaperonin containing TCP1 subunit 4 (delta) or CCT4 is a molecular chaperone. It assists with the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex, it may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. It is also known to play a role, in vitro, in the folding of actin and tubulin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P50991].
Description (Vector)
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 (PubMed 9819444)).(supplied by OMIM, Mar 2008)
Gene ID
10575
Gene Name (eCommerce)
chaperonin containing TCP1 subunit 4
Gene Name (Vector)
chaperonin containing TCP1 subunit 4
Gene Symbol
CCT4
HGNC ID
HGNC:1617
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1620
ORF Size (bp)
1620 bp
Protein Name (eCommerce)
T-complex protein 1 subunit delta
RefSeq ID
NM_006430
RefSeq Synonyms
NM_006430, NM_001256721, BC106934, BC106933,
Research Areas
Cytoskeleton,Immunology,Metabolism/Metabolic Process,Protein Folding,Translational Control,Transport
Research Areas (Faceted)
cell_biology,immunology,metabolism,transcription_translation
Species
human
Target Sentence
Chaperonin containing TCP1 subunit 4 (delta) or CCT4 is a molecular chaperone. It assists with the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex, it may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. It is also known to play a role, in vitro, in the folding of actin and tubulin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P50991].
UniGene ID
Hs.421509
UniProt ID (eCommerce)
P50991

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.