mouse USP20 Adenovirus
This is an Adenovirus expressing Mouse Usp20.
ADV-275721
Ad-m-USP20
Ready-to-use Adenovirus expressing Mouse Usp20 (ubiquitin specific peptidase 20). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1700055M05Rik; AI467231; Vdu2
Description (Vector)
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene ID
74270
Gene Name (Vector)
ubiquitin specific peptidase 20
Gene Symbol
Usp20
ORF Size (aa)
2751
ORF Size (bp)
2751 bp
RefSeq ID
NM_028846
RefSeq Synonyms
NM_028846, BC079674,
Species
mouse
UniGene ID
Mm.346654
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.