mouse TRIM24 Adenovirus
This is an Adenovirus expressing Mouse Trim24.
ADV-274975
Ad-m-TRIM24
Ready-to-use Adenovirus expressing Mouse Trim24 (tripartite motif-containing 24). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A130082H20Rik; AI447469; D430004I05Rik; TIF1; TIF1-alpha; Tif1a; TIF1alpha
Description (Vector)
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Gene ID
21848
Gene Name (Vector)
tripartite motif-containing 24
Gene Symbol
Trim24
ORF Size (aa)
3156
ORF Size (bp)
3156 bp
RefSeq ID
NM_145076
RefSeq Synonyms
NM_145076, NM_001272076, NM_001272064, BC056959,
Species
mouse
UniGene ID
Mm.41063
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.