mouse TAP1 Adenovirus
This is an Adenovirus expressing Mouse Tap1.
ADV-273691
Ad-m-TAP1
Ready-to-use Adenovirus expressing Mouse Tap1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1; PSF1; RING4; TAP; Tap-1; Y3
Description (Vector)
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Gene ID
21354
Gene Name (Vector)
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Symbol
Tap1
ORF Size (aa)
1734
ORF Size (bp)
1734 bp
RefSeq ID
NM_013683
RefSeq Synonyms
NM_013683, NM_001161730, BC024897, BC013802,
Species
mouse
UniGene ID
Mm.207996
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.