mouse PIWIL1 Adenovirus
This is an Adenovirus expressing Mouse Piwil1.
ADV-268717
Ad-m-PIWIL1
Ready-to-use Adenovirus expressing Mouse Piwil1 (piwi-like RNA-mediated gene silencing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MIWI
Description (Vector)
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.
Gene ID
57749
Gene Name (Vector)
piwi-like RNA-mediated gene silencing 1
Gene Symbol
Piwil1
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
RefSeq ID
NM_021311
RefSeq Synonyms
NM_021311, BC129858, BC129857,
Species
mouse
UniGene ID
Mm.272720
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.