mouse MSH6 Adenovirus
This is an Adenovirus expressing Mouse Msh6.
ADV-265049
Ad-m-MSH6
Ready-to-use Adenovirus expressing Mouse Msh6 (mutS homolog 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU044881; AW550279; GTBP; Gtmbp
Description (Vector)
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair.
Gene ID
17688
Gene Name (Vector)
mutS homolog 6
Gene Symbol
Msh6
ORF Size (aa)
4077
ORF Size (bp)
4077 bp
RefSeq ID
NM_010830
RefSeq Synonyms
NM_010830, BC051634, BC051160,
Species
mouse
UniGene ID
Mm.18210
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.