mouse MLH1 Adenovirus
This is an Adenovirus expressing Human STK31.
ADV-264688
Ad-m-MLH1
Ready-to-use Adenovirus expressing Mouse Mlh1 (mutL homolog 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110035C23Rik; AI317206; AI325952; AI561766
Description (Vector)
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
Gene ID
17350
Gene Name (Vector)
mutL homolog 1
Gene Symbol
Mlh1
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
RefSeq ID
NM_026810
RefSeq Synonyms
NM_026810, NM_001324522, BC021815,
Species
mouse
UniGene ID
Mm.196006
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.