mouse MAF Adenovirus
This is an Adenovirus expressing Human SPPL2A.
ADV-264080
Ad-m-MAF
Ready-to-use Adenovirus expressing Mouse Maf (avian musculoaponeurotic fibrosarcoma oncogene homolog). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810401A20Rik; A230108G15Rik; avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog; AW047063; c-maf; c-Maf long form; proto-oncogene c-maf; transcription factor Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Description (eCommerce)
c-Maf is part of the Maf family of transcription factors that possess a conserved basic region and a leucine zipper domain that mediate DNA and protein-protein binding and plays an important role in tissue-specific gene regulation and cell differentiation. c-Maf is a transcriptional activator of interleukin 4 and 10 in T-cells, and is involved in lens fiber cell differentiation. c-Maf translocation has been observed in human multiple myeloma and may be oncogenic.
Description (Vector)
Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.
Gene ID
17132
Gene Name (eCommerce)
avian musculoaponeurotic fibrosarcoma oncogene homolog
Gene Name (Vector)
avian musculoaponeurotic fibrosarcoma oncogene homolog
Gene Symbol
Maf
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1110
ORF Size (bp)
1110 bp
Protein Name (eCommerce)
Transcription factor Maf
RefSeq ID
NM_001025577
RefSeq Synonyms
NM_001025577, BC156038,
Research Areas
Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
mouse
Target Sentence
c-Maf is part of the Maf family of transcription factors that possess a conserved basic region and a leucine zipper domain that mediate DNA and protein-protein binding and plays an important role in tissue-specific gene regulation and cell differentiation. c-Maf is a transcriptional activator of interleukin 4 and 10 in T-cells, and is involved in lens fiber cell differentiation. c-Maf translocation has been observed in human multiple myeloma and may be oncogenic.
UniGene ID
Mm.439772
UniProt ID (eCommerce)
P54843
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.