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human C19ORF62 Over-expression AAV

Name 
AAV-h-C19ORF62
Cat No 
AAV-202946
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BABAM1.

AAV-202946
AAV-h-C19ORF62

Ready-to-use AAV expressing Human BABAM1 (BRISC and BRCA1 A complex member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; C19orf62; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; NBA1; new component of the BRCA1-A complex; new component of the BRCAA1 A complex
Description (eCommerce)
MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
Gene ID
29086
Gene Name (eCommerce)
BRISC and BRCA1 A complex member 1
Gene Name (Vector)
BRISC and BRCA1 A complex member 1
Gene Symbol
BABAM1
HGNC ID
HGNC:25008
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
990
ORF Size (bp)
990 bp
Protein Name (eCommerce)
BRISC and BRCA1-A complex member 1
RefSeq ID
NM_014173
RefSeq Synonyms
NM_014173, NM_001288757, NM_001288756, NM_001033549, BC091491, BC006244, BC000788,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
UniGene ID
Hs.190722
UniProt ID (eCommerce)
Q9NWV8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.