mouse GABBR1 Adenovirus

Name
Ad-m-GABBR1

Cat No
ADV-259789

Availability
4-5 weeks

This is an Adenovirus expressing Mouse GABBR1.

ADV-259789

Ad-m-GABBR1

Ready-to-use Adenovirus expressing Mouse Gabbr1 (gamma-aminobutyric acid (GABA) B receptor, 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

bM573K1.1; GABAB1; GABAbR1

Description (Vector)

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen|Function: Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Gene ID

54393

Gene Name (Vector)

gamma-aminobutyric acid (GABA) B receptor, 1

Gene Symbol

Gabbr1

ORF Size (aa)

2883

ORF Size (bp)

2883 bp

RefSeq ID

NM_019439

RefSeq Synonyms

NM_019439, BC056990, BC054735,

Species

mouse

UniGene ID

Mm.32191

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.