mouse FEN1 Adenovirus
This is an Adenovirus expressing Human ARHGAP36.
ADV-259321
Ad-m-FEN1
Ready-to-use Adenovirus expressing Mouse Fen1 (flap structure specific endonuclease 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW538437; FEN-1
Description (Vector)
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Gene ID
14156
Gene Name (Vector)
flap structure specific endonuclease 1
Gene Symbol
Fen1
ORF Size (aa)
1143
ORF Size (bp)
1143 bp
RefSeq ID
NM_007999
RefSeq Synonyms
NM_007999, NM_001271615, NM_001271614, BC027295, BC010203,
Species
mouse
UniGene ID
Mm.470595
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.