mouse EPAS1 Adenovirus
This is an Adenovirus expressing Mouse Epas1.
ADV-258542
Ad-m-EPAS1
Ready-to-use Adenovirus expressing Mouse Epas1 (endothelial PAS domain protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bHLHe73; HIF-2alpha; HIF2A; HLF; HRF; MOP2
Description (Vector)
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Gene ID
13819
Gene Name (Vector)
endothelial PAS domain protein 1
Gene Symbol
Epas1
ORF Size (aa)
2625
ORF Size (bp)
2625 bp
RefSeq ID
NM_010137
RefSeq Synonyms
NM_010137, BC057870,
Species
mouse
UniGene ID
Mm.1415
Related Citations
- Estrogen-related receptor ¿ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. YO Son, etc, (2017), Nature Communicationsvolume
- Upregulation of Atrogin-1/FBXO32 is not necessary for cartilage destruction in mouse models of osteoarthritis. Kim HE, etc, (2016), Osteoarthritis and Cartilage
- HIF-2a in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. Dehn S etc,, (2016), The Journal of Immunolog
- Reciprocal regulation by hypoxia-inducible factor-2a and the NAMPT-NAD+-SIRT axis in articular chondrocytes is involved in osteoarthritis. Hwanhee Oh, etc, (2015), Osteoarthritis and Cartilage
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.