mouse DYRK2 Adenovirus
This is an Adenovirus expressing Mouse DYRK2.
ADV-257593
Ad-m-DYRK2
Ready-to-use Adenovirus expressing Mouse Dyrk2 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810038L18Rik
Description (Vector)
Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. Phosphorylates CRMP4/DPYSL3, EIF2B5, GYS1, p53/TP53, TAU/MAPT, STAT3 and KATNA1. Regulates p53/TP53 by phosphorylation on 'Ser-46' to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of its downstream substrate, KATNA1. Phosphorylation of CRMP4/DPYSL3 promotes its subsequent phosphorylation by GSK3.
Gene ID
69181
Gene Name (Vector)
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Gene Symbol
Dyrk2
ORF Size (aa)
1800
ORF Size (bp)
1800 bp
RefSeq ID
NM_001014390
RefSeq Synonyms
NM_001014390, BC085145,
Species
mouse
UniGene ID
Mm.458174
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.