mouse DIS3 Adenovirus
This is an Adenovirus expressing Mouse DIS3.
ADV-257196
Ad-m-DIS3
Ready-to-use Adenovirus expressing Mouse Dis3 (DIS3 homolog, exosome endoribonuclease and 3′-5′ exoribonuclease). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810028N01Rik
Description (Vector)
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
Gene ID
72662
Gene Name (Vector)
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Gene Symbol
Dis3
ORF Size (aa)
1701
ORF Size (bp)
1701 bp
RefSeq ID
NM_028315
RefSeq Synonyms
NM_028315, BC027357,
Species
mouse
UniGene ID
Mm.163339
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.