mouse DCLRE1C Adenovirus

Name 
Ad-m-DCLRE1C
Cat No 
ADV-256853
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse DCLRE1C.

ADV-256853
Ad-m-DCLRE1C

Ready-to-use Adenovirus expressing Mouse Dclre1c (DNA cross-link repair 1C). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
9930121L06Rik; AI661365; Art; DNA cross-link repair 1A, PSO2 homolog; DNA cross-link repair 1C protein; DNA cross-link repair 1C, PSO2 homolog; mArt; protein artemis; Snm1l; SNM1-like protein
Description (eCommerce)
Artemis is also known as DNA cross-link repair 1C protein (DCLRE1C) and functions as both an endo- and exo-nuclease involved in V(D)J recombination and double-strand break (DSB) repair. In addition to repair of double stranded breaks during V(D)J recombination, Artemis may also be required for repair of ionizing radiation induced DSBs. Mutations in Artemis have been found to be a cause of severe combined immunodeficiency (SCID).
Description (Vector)
Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Gene ID
227525
Gene Name (eCommerce)
DNA cross-link repair 1C
Gene Name (Vector)
DNA cross-link repair 1C
Gene Symbol
Dclre1c
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1461
ORF Size (bp)
1461 bp
Protein Name (eCommerce)
Protein artemis
RefSeq ID
NM_146114
RefSeq Synonyms
NM_175683, NM_146114, NM_001302684, NM_001302674, NM_001110214, BC108935,
Research Areas
DNA Damage/Repair,Immunology,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
mouse
Target Sentence
Artemis is also known as DNA cross-link repair 1C protein (DCLRE1C) and functions as both an endo- and exo-nuclease involved in V(D)J recombination and double-strand break (DSB) repair. In addition to repair of double stranded breaks during V(D)J recombination, Artemis may also be required for repair of ionizing radiation induced DSBs. Mutations in Artemis have been found to be a cause of severe combined immunodeficiency (SCID).
UniGene ID
Mm.442710
UniProt ID (eCommerce)
Q8K4J0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.