human C10ORF54 Over-expression AAV

Name
AAV-h-C10ORF54

Cat No
AAV-202428

Availability
4-5 weeks

This is an AAV expressing Human VSIR.

AAV-202428

AAV-h-C10ORF54

Ready-to-use AAV expressing Human VSIR (V-set immunoregulatory receptor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B7H5; B7-H5; C10orf54; DD1alpha; Death Domain1alpha; GI24; PD-1H; PDCD1 homolog; platelet receptor GI24; PP2135; SISP1; sisp-1; stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation

Description (eCommerce)

VISTA is an immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). VISTA may stimulate MMP14-mediated MMP2 activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H7M9].

Gene ID

64115

Gene Name (eCommerce)

V-set immunoregulatory receptor

Gene Name (Vector)

V-set immunoregulatory receptor

Gene Symbol

VSIR

HGNC ID

HGNC:30085

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

936

ORF Size (bp)

936 bp

Protein Name (eCommerce)

V-type immunoglobulin domain-containing suppressor of T-cell activation

RefSeq ID

NM_022153

RefSeq Synonyms

NM_022153, BC020568,

Research Areas

Cell Biology,Immunology,Signal Transduction,Transport

Research Areas (Faceted)

signal_transduction,cell_biology,immunology,cell_biology

Species

human

Target Sentence

VISTA is an immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). VISTA may stimulate MMP14-mediated MMP2 activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H7M9].

UniGene ID

Hs.47382

UniProt ID (eCommerce)

Q9H7M9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.