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human BCCIP Over-expression AAV

Name 
AAV-h-BCCIP
Cat No 
AAV-202023
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BCCIP.

AAV-202023
AAV-h-BCCIP

Ready-to-use AAV expressing Human BCCIP (BRCA2 and CDKN1A interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BCCIPalpha; BCCIPbeta; BRCA2 and CDKN1A-interacting protein; BRCA2 and Cip1/p21 interacting protein; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; protein TOK-1; TOK1; TOK-1; TOK-1alpha; TOK-1beta
Description (eCommerce)
BCCIP (BRCA2 and CDKN1A interacting protein) was isolated as a BRCA2 and p21 interacting protein. Downregulation of BCCIP results in chromosome instability and incomplete cytokinesis indicating a role in DNA damage. Additionally, BCCIP is critical for BRCA2- and Rad51-dependent homologous recombinational repair.
Description (Vector)
BCCIP product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Gene ID
56647
Gene Name (eCommerce)
BRCA2 and CDKN1A interacting protein
Gene Name (Vector)
BRCA2 and CDKN1A interacting protein
Gene Symbol
BCCIP
HGNC ID
HGNC:978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
945
ORF Size (bp)
945 bp
Protein Name (eCommerce)
BRCA2 and CDKN1A-interacting protein
RefSeq ID
NM_078469
RefSeq Synonyms
NM_078469, NM_078468, NM_016567, BC009771,
Research Areas
Cell Cycle,Cell Division,DNA Damage/Repair,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,neurobiology,developmental_biology
Species
human
Target Sentence
BCCIP (BRCA2 and CDKN1A interacting protein) was isolated as a BRCA2 and p21 interacting protein. Downregulation of BCCIP results in chromosome instability and incomplete cytokinesis indicating a role in DNA damage. Additionally, BCCIP is critical for BRCA2- and Rad51-dependent homologous recombinational repair.
UniGene ID
Hs.715543
UniProt ID (eCommerce)
Q9P287

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.