human HLA-DRB5 Adenovirus
This is an Adenovirus expressing Human MYOCD.
ADV-232367
Ad-h-HLA-DRB5
Ready-to-use Adenovirus expressing Human HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Gene ID
3127
Gene Name (Vector)
major histocompatibility complex, class II, DR beta 5
Gene Symbol
HLA-DRB5
HGNC ID
HGNC:4953
ORF Size (aa)
801
ORF Size (bp)
801 bp
RefSeq ID
NM_002125
RefSeq Synonyms
NM_002125, BC009234,
Species
human
UniGene ID
Hs.
Related Citations
- Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle. B Zhu, etc, (2020), Journal of Cellular Physiology
- Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP. B Zhu, etc, (2018), Scientific Reports
- Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle. Zhu B, etc, (2017), PLoS ONE
- Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. Alajbegovic A, etc, (2016), Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.