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human KIR2DS2 Adenovirus

Name 
Ad-h-KIR2DS2
Cat No 
ADV-232291
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human KIR2DS2.

ADV-232291
Ad-h-KIR2DS2

Ready-to-use Adenovirus expressing Human KIR2DS2 (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
183ActI; CD158b; CD158J; cl-49; KIR-2DS2; NKAT-5; NKAT5
Description (Vector)
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Gene ID
100132285
Gene Name (Vector)
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
Gene Symbol
KIR2DS2
HGNC ID
HGNC:6334
ORF Size (aa)
1017
ORF Size (bp)
1017 bp
RefSeq ID
NM_012312
RefSeq Synonyms
NM_012312, NM_001291701, NM_001291700, NM_001291696, NM_001291695, BC126856, BC119632, BC119631, BC108917,
Species
human
UniGene ID
Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.