human ATP6V0C Over-expression AAV
This is an AAV expressing Human ATP6V0C.
AAV-201748
AAV-h-ATP6V0C
Ready-to-use AAV expressing Human ATP6V0C (ATPase H+ transporting V0 subunit c). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP6C; ATP6L; ATPL; VATL; Vma3; VPPC
Description (Vector)
ATP6V0C encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. ATP6V0C encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
Gene ID
527
Gene Name (Vector)
ATPase H+ transporting V0 subunit c
Gene Symbol
ATP6V0C
HGNC ID
HGNC:855
ORF Size (aa)
468
ORF Size (bp)
468 bp
RefSeq ID
NM_001694
RefSeq Synonyms
NM_001694, NM_001198569, BC009290, BC007759, BC007389, BC004537,
Species
human
UniGene ID
Hs.389107
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.