human DOCK7 Adenovirus

Name
Ad-h-DOCK7

Cat No
ADV-229290

Availability
4-5 weeks

This is an Adenovirus expressing Human DOCK7.

ADV-229290

Ad-h-DOCK7

Ready-to-use Adenovirus expressing Human DOCK7 (dedicator of cytokinesis 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

dedicator of cytokinesis protein 7; EIEE23; ZIR2

Description (eCommerce)

Dedicator of cytokinesis protein 7 (DOCK7) functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. DOCK7 does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96N67].

Gene ID

85440

Gene Name (eCommerce)

dedicator of cytokinesis 7

Gene Name (Vector)

dedicator of cytokinesis 7

Gene Symbol

DOCK7

HGNC ID

HGNC:19190

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

6327

ORF Size (bp)

6327 bp

Protein Name (eCommerce)

Dedicator of cytokinesis protein 7

RefSeq ID

NM_033407

RefSeq Synonyms

NM_033407, NM_001330614, NM_001272002, NM_001272001, NM_001272000, NM_001271999, BC172250,

Research Areas

Axonogenesis,Cytoskeleton,Immunology,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction

Research Areas (Faceted)

signal_transduction,neurobiology,developmental_biology,cell_biology,immunology,neurobiology,developmental_biology

Species

human

Target Sentence

Dedicator of cytokinesis protein 7 (DOCK7) functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. DOCK7 does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96N67].

UniGene ID

Hs.406156

UniProt ID (eCommerce)

Q96N67

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.