human ATF2 Over-expression AAV
This is an AAV expressing Human ATF2.
AAV-201615
AAV-h-ATF2
Ready-to-use AAV expressing Human ATF2 (activating transcription factor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CREB2; CREB-2; CRE-BP1; cyclic AMP-dependent transcription factor ATF-2; cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; TREB7
Description (eCommerce)
Activating transcription factor 2 (ATF2) is a leucine-zipper transcription factor that binds to the cAMP-responsive element (CRE). ATF2 is involved in regulating the expression of a variety of proteins that are important to oncogenesis. It is a substrate of the JNK/p38 and ATM/ATR protein kinases which regulate its transactivating activity in response to environmental signals.
Description (Vector)
ATF2 encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
Gene ID
1386
Gene Name (eCommerce)
activating transcription factor 2
Gene Name (Vector)
activating transcription factor 2
Gene Symbol
ATF2
HGNC ID
HGNC:784
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1344
ORF Size (bp)
1344 bp
Protein Name (eCommerce)
Cyclic AMP-dependent transcription factor ATF-2
RefSeq ID
NM_001880
RefSeq Synonyms
NM_001880, NM_001256094, NM_001256093, NM_001256092, NM_001256091, NM_001256090, BC130337, BC130335, BC107698, BC026175,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,DNA Damage/Repair,Estrogen Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,PI3K/Akt Signaling,RAC1 Signaling,Rho Signaling,RNA Binding,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Viral Carcinogenesis,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Activating transcription factor 2 (ATF2) is a leucine-zipper transcription factor that binds to the cAMP-responsive element (CRE). ATF2 is involved in regulating the expression of a variety of proteins that are important to oncogenesis. It is a substrate of the JNK/p38 and ATM/ATR protein kinases which regulate its transactivating activity in response to environmental signals.
UniGene ID
Hs.592510
UniProt ID (eCommerce)
P15336
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.