human UMPS Adenovirus

Name 
Ad-h-UMPS
Cat No 
ADV-227178
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human UMPS.

ADV-227178
Ad-h-UMPS

Ready-to-use Adenovirus expressing Human UMPS (uridine monophosphate synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
OMPdecase; OPRT; OPRTase; orotate phosphoribosyltransferase; Orotate phosphoribosyltransferase (OPRT); orotidine 5'-phosphate decarboxylase; Orotidine 5'-phosphate decarboxylase (ODC); UMP synthase; uridine 5'-monophosphate synthase
Description (eCommerce)
UMPS (uridine monophosphate synthase) is a uridine 5'-monophosphate synthase. UMPS is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate [taken from NCBI Entrez Gene (Gene ID: 7372)].
Description (Vector)
UMPS encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
Gene ID
7372
Gene Name (eCommerce)
uridine monophosphate synthetase
Gene Name (Vector)
uridine monophosphate synthetase
Gene Symbol
UMPS
HGNC ID
HGNC:12563
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1443
ORF Size (bp)
1443 bp
Protein Name (eCommerce)
Uridine 5'-monophosphate synthase
RefSeq ID
NM_000373
RefSeq Synonyms
NM_000373, BC007511, BC000364,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
UMPS (uridine monophosphate synthase) is a uridine 5'-monophosphate synthase. UMPS is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate [taken from NCBI Entrez Gene (Gene ID: 7372)].
UniGene ID
Hs.2057
UniProt ID (eCommerce)
P11172

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.