human ARRB2 Over-expression AAV

Name 
AAV-h-ARRB2
Cat No 
AAV-201476
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ARRB2.

AAV-201476
AAV-h-ARRB2

Ready-to-use AAV expressing Human ARRB2 (arrestin beta 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARB2; ARR2; arrestin 3; Arrestin beta-2; BARR2; beta-arrestin-2; non-visual arrestin-3
Description (eCommerce)
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 2, like beta-arrestin 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for beta-arrestin 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. [taken from NCBI Entrez Gene (Gene ID: 409)].
Gene ID
409
Gene Name (eCommerce)
arrestin beta 2
Gene Name (Vector)
arrestin beta 2
Gene Symbol
ARRB2
HGNC ID
HGNC:712
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1230
ORF Size (bp)
1230 bp
Protein Name (eCommerce)
Beta-arrestin-2
RefSeq ID
NM_004313
RefSeq Synonyms
NM_199004, NM_004313, NM_001330064, NM_001257331, NM_001257330, NM_001257329, NM_001257328, BC067368, BC007427,
Research Areas
Cancer,Cardiology,Cardiovascular,Hedgehog Signaling,Immunology,Interleukin Signaling,MAPK Signaling,Neurobiology,NF-kB Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 2, like beta-arrestin 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for beta-arrestin 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. [taken from NCBI Entrez Gene (Gene ID: 409)].
UniGene ID
Hs.435811
UniProt ID (eCommerce)
P32121

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.