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human TNFAIP3 Adenovirus

Name 
Ad-h-TNFAIP3
Cat No 
ADV-226059
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TNFAIP3.

ADV-226059
Ad-h-TNFAIP3

Ready-to-use Adenovirus expressing Human TNFAIP3 (TNF alpha induced protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A20; AISBL; OTU domain-containing protein 7C; OTUD7C; putative DNA-binding protein A20; TNF alpha-induced protein 3; TNFA1P2; tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; zinc finger protein A20
Description (eCommerce)
Zinc-finger protein A20 was identified as a transcript that was rapidly induced by tumor-necrosis factor alpha (TNF-alpha). A20 is an essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, A20 deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21580].
Description (Vector)
TNFAIP3 was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
Gene ID
7128
Gene Name (eCommerce)
TNF alpha induced protein 3
Gene Name (Vector)
TNF alpha induced protein 3
Gene Symbol
TNFAIP3
HGNC ID
HGNC:11896
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2373
ORF Size (bp)
2373 bp
Protein Name (eCommerce)
Tumor necrosis factor alpha-induced protein 3
RefSeq ID
NM_006290
RefSeq Synonyms
NM_006290, NM_001270508, NM_001270507, BC114480, BC113871, BC064689,
Research Areas
Apoptosis,Cancer,CD40 Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Lysosome,NF-kB Signaling,Response to Virus,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Zinc-finger protein A20 was identified as a transcript that was rapidly induced by tumor-necrosis factor alpha (TNF-alpha). A20 is an essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, A20 deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21580].
UniGene ID
Hs.211600
UniProt ID (eCommerce)
P21580

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.