human ARHGEF6 Over-expression AAV

Name
AAV-h-ARHGEF6

Cat No
AAV-201372

Availability
4-5 weeks

This is an AAV expressing Human ARHGEF6.

AAV-201372

AAV-h-ARHGEF6

Ready-to-use AAV expressing Human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

alphaPIX; alpha-PIX; COOL2; Cool-2; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; rho guanine nucleotide exchange factor 6

Description (eCommerce)

Rho guanine nucleotide exchange factor 6 (ARHGEF6) functions as a guanine nucleotide exchange factor (GEF) for RAC1. ARHGEF6 was originally identified as a binding partner of p21 activated kinase (Pak) and was termed Pix (Pak interactive exchange factor).

Description (Vector)

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

Gene ID

9459

Gene Name (eCommerce)

Rac/Cdc42 guanine nucleotide exchange factor 6

Gene Name (Vector)

Rac/Cdc42 guanine nucleotide exchange factor 6

Gene Symbol

ARHGEF6

HGNC ID

HGNC:685

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2331

ORF Size (bp)

2331 bp

Protein Name (eCommerce)

Rho guanine nucleotide exchange factor 6

RefSeq ID

NM_004840

RefSeq Synonyms

NM_004840, NM_001306177, BC043505, BC039856,

Research Areas

Apoptosis,Cancer,Cytoskeleton,GPCR Signaling,Immunology,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling

Research Areas (Faceted)

cancer,signal_transduction,cell_biology,immunology,neurobiology,developmental_biology,signal_transduction,immunology

Species

human

Target Sentence

UniGene ID

Hs.522795

UniProt ID (eCommerce)

Q15052

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.