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human THOC2 Adenovirus

Name 
Ad-h-THOC2
Cat No 
ADV-225449
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human THOC2.

ADV-225449
Ad-h-THOC2

Ready-to-use Adenovirus expressing Human THOC2 (THO complex 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CXorf3; dJ506G2.1; hTREX120; mental retardation, X-linked 12; mental retardation, X-linked 35; MRX12; MRX35; THO complex subunit 2; THO2
Description (eCommerce)
THO complex subunit 2 (THOC2) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. THOC2 binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8NI27].
Description (Vector)
The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.
Gene ID
57187
Gene Name (eCommerce)
THO complex 2
Gene Name (Vector)
THO complex 2
Gene Symbol
THOC2
HGNC ID
HGNC:19073
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4434
ORF Size (bp)
4434 bp
Protein Name (eCommerce)
THO complex subunit 2
RefSeq ID
NM_001081550
RefSeq Synonyms
NM_001081550, BC172220,
Research Areas
Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,mRNA transport,RNA Binding,RNA Processing,RNA Transport,Spliceosome,Transport
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,cell_biology
Species
human
Target Sentence
THO complex subunit 2 (THOC2) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. THOC2 binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8NI27].
UniGene ID
Hs.592243
UniProt ID (eCommerce)
Q8NI27

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.