human APBA1 Over-expression AAV

Name 
AAV-h-APBA1
Cat No 
AAV-201117
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human APBA1.

AAV-201117
AAV-h-APBA1

Ready-to-use AAV expressing Human APBA1 (amyloid beta precursor protein binding family A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
adapter protein X11alpha; adaptor protein X11alpha; amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid-beta A4 precursor protein-binding family A member 1; D9S411E; LIN10; MINT1; mint-1; neuronal munc18-1-interacting protein 1; neuron-specific X11 protein; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11; X11A; X11ALPHA
Description (eCommerce)
Amyloid beta A4 precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients [taken from NCBI Entrez Gene (Gene ID: 320)].
Description (Vector)
APBA1 is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Gene ID
320
Gene Name (eCommerce)
amyloid beta precursor protein binding family A member 1
Gene Name (Vector)
amyloid beta precursor protein binding family A member 1
Gene Symbol
APBA1
HGNC ID
HGNC:578
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2514
ORF Size (bp)
2514 bp
Protein Name (eCommerce)
Amyloid beta A4 precursor protein-binding family A member 1
RefSeq ID
NM_001163
RefSeq Synonyms
NM_001163, BC157030, BC156047,
Research Areas
Golgi Apparatus,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
Amyloid beta A4 precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients [taken from NCBI Entrez Gene (Gene ID: 320)].
UniGene ID
Hs.592974
UniProt ID (eCommerce)
Q02410

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.