human AP4B1 Over-expression AAV

Name
AAV-h-AP4B1

Cat No
AAV-201108

Availability
4-5 weeks

This is an AAV expressing Human AP4B1.

AAV-201108

AAV-h-AP4B1

Ready-to-use AAV expressing Human AP4B1 (adaptor related protein complex 4 beta 1 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BETA-4; CPSQ5; SPG47

Description (Vector)

AP4B1 encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

10717

Gene Name (Vector)

adaptor related protein complex 4 beta 1 subunit

Gene Symbol

AP4B1

HGNC ID

HGNC:572

ORF Size (aa)

2220

ORF Size (bp)

2220 bp

RefSeq ID

NM_006594

RefSeq Synonyms

NM_006594, NM_001308312, NM_001253853, NM_001253852, BC014146,

Species

human

UniGene ID

Hs.515048

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.