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human SLBP Adenovirus

Name 
Ad-h-SLBP
Cat No 
ADV-223065
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SLBP.

ADV-223065
Ad-h-SLBP

Ready-to-use Adenovirus expressing Human SLBP (stem-loop binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hairpin binding protein, histone; HBP; histone binding protein; histone RNA hairpin-binding protein; histone stem-loop binding protein; Histone stem-loop-binding protein; stem-loop (histone) binding protein
Description (eCommerce)
Stem-loop-binding protein (SLBP) is an RNA-binding protein involved in the histone pre-mRNA processing. SLBP binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). SLBP plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. It stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. It is also involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. SLBP binds to the 5' side of the stem-loop structure of histone pre-mRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14493].
Description (Vector)
SLBP encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
Gene ID
7884
Gene Name (eCommerce)
stem-loop binding protein
Gene Name (Vector)
stem-loop binding protein
Gene Symbol
SLBP
HGNC ID
HGNC:10904
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
813
Protein Name (eCommerce)
Histone RNA hairpin-binding protein
RefSeq ID
NM_006527
RefSeq Synonyms
NM_006527, NM_001306075, NM_001306074, BC015703, BC014908,
Research Areas
Cell Cycle,DNA Replication,Gene Expression,mRNA Binding,mRNA Processing,mRNA Transport,Replication,RNA Binding,RNA Processing,RNA Transport,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Stem-loop-binding protein (SLBP) is an RNA-binding protein involved in the histone pre-mRNA processing. SLBP binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). SLBP plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. It stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. It is also involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. SLBP binds to the 5' side of the stem-loop structure of histone pre-mRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14493].
UniGene ID
Hs.298345
UniProt ID (eCommerce)
Q14493

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.